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ITSN2 |
intersectin 2 |
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- RHOU GTPase cycle
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KDM1A |
lysine demethylase 1A |
- HDACs deacetylate histones
- HDMs demethylate histones
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- Potential therapeutics for SARS
- Negative Regulation of CDH1 Gene Transcription
- Factors involved in megakaryocyte development and platelet production
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KLC3 |
kinesin light chain 3 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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KLC4 |
kinesin light chain 4 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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KRAS |
KRAS proto-oncogene, GTPase |
- Signaling by moderate kinase activity BRAF mutants
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- RUNX3 regulates p14-ARF
- RAS processing
- Signaling downstream of RAS mutants
- Signaling by CSF3 (G-CSF)
- Signaling by CSF1 (M-CSF) in myeloid cells
- Signaling by RAS GAP mutants
- Signaling by RAS GTPase mutants
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- [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
- Farnesyl diphosphate
- Adagrasib
- Sotorasib
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- Acute myeloid leukemia (AML)
- Oral cancer
- Non-small cell lung cancer
- Multiple myeloma
- Cervical cancer
- Kaposi's sarcoma
- Cholangiocarcinoma
- Gallbladder cancer
- Gastric cancer
- Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
- Ovarian cancer
- Hepatocellular carcinoma
- Thyroid cancer
- Squamous cell carcinoma
- Colorectal cancer
- Endometrial Cancer
- Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
- Pancreatic cancer
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KRT18 |
keratin 18 |
- Keratinization
- Formation of the cornified envelope
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Alveolar Cells
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KRT31 |
keratin 31 |
- Keratinization
- Formation of the cornified envelope
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LAMTOR3 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- MAP2K and MAPK activation
- Neutrophil degranulation
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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LENG1 |
leukocyte receptor cluster member 1 |
- mRNA Splicing - Major Pathway
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LIN37 |
lin-37 DREAM MuvB core complex component |
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- G0 and Early G1
- Polo-like kinase mediated events
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- Cyclin A:Cdk2-associated events at S phase entry
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LMO4 |
LIM domain only 4 |
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MAPRE3 |
microtubule associated protein RP/EB family member 3 |
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MIF4GD |
MIF4G domain containing |
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MTUS2 |
microtubule associated scaffold protein 2 |
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MYBPC2 |
myosin binding protein C2 |
- Striated Muscle Contraction
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MYOM1 |
myomesin 1 |
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NAA10 |
N-alpha-acetyltransferase 10, NatA catalytic subunit |
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NEFL |
neurofilament light chain |
- Unblocking of NMDA receptors, glutamate binding and activation
- Unblocking of NMDA receptors, glutamate binding and activation
- Ras activation upon Ca2+ influx through NMDA receptor
- RAF/MAP kinase cascade
- Assembly and cell surface presentation of NMDA receptors
- Negative regulation of NMDA receptor-mediated neuronal transmission
- Long-term potentiation
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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NEK2 |
NIMA related kinase 2 |
- APC-Cdc20 mediated degradation of Nek2A
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
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- 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide
- Fostamatinib
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OSGEP |
O-sialoglycoprotein endopeptidase |
- tRNA modification in the nucleus and cytosol
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