EXOSC5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide
KRT35	keratin 35	Keratinization Formation of the cornified envelope
LCA5L	lebercilin LCA5 like
LIPG	lipase G, endothelial type	HDL remodeling
LRMDA	leucine rich melanocyte differentiation associated
LSM3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
LSM5	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
LZTS2	leucine zipper tumor suppressor 2
MEOX2	mesenchyme homeobox 2
MPHOSPH6	M-phase phosphoprotein 6	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
MTMR3	myotubularin related protein 3	Macroautophagy Synthesis of PIPs at the plasma membrane
MTREX	Mtr4 exosome RNA helicase	Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
MYLIP	myosin regulatory light chain interacting protein	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
NKAPD1	NKAP domain containing 1
NMI	N-myc and STAT interactor	SARS-CoV-1 activates/modulates innate immune responses
NUP210	nucleoporin 210	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
PA2G4	proliferation-associated 2G4	Neutrophil degranulation
PALS2	protein associated with LIN7 2, MAGUK p55 family member
PEG10	paternally expressed 10
PICK1	protein interacting with PRKCA 1	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
PIH1D2	PIH1 domain containing 2

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