TRIM32 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
GLIS2	GLIS family zinc finger 2			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GPR137B	G protein-coupled receptor 137B
HSPA4	heat shock protein family A (Hsp70) member 4	Regulation of HSF1-mediated heat shock response	Phenethyl Isothiocyanate
ICMT	isoprenylcysteine carboxyl methyltransferase	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing
IQCB1	IQ motif containing B1	Anchoring of the basal body to the plasma membrane		Senior-Loken syndrome
IRAK1	interleukin 1 receptor associated kinase 1	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Fostamatinib
KCTD9	potassium channel tetramerization domain containing 9
LCN2	lipocalin 2	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport	Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
MAP1LC3A	microtubule associated protein 1 light chain 3 alpha	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
MAP1LC3B	microtubule associated protein 1 light chain 3 beta	Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy KEAP1-NFE2L2 pathway
MAP1LC3C	microtubule associated protein 1 light chain 3 gamma	Macroautophagy
MID2	midline 2
MOB1A	MOB kinase activator 1A	Signaling by Hippo
MYCN	MYCN proto-oncogene, bHLH transcription factor	Signaling by ALK Regulation of CDH1 mRNA translation by microRNAs TGFBR3 expression Regulation of PD-L1(CD274) transcription		Neuroblastoma Feingold syndrome
NDRG2	NDRG family member 2
NTAQ1	N-terminal glutamine amidase 1
PDE9A	phosphodiesterase 9A	cGMP effects	Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
PELI2	pellino E3 ubiquitin protein ligase family member 2	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PIAS3	protein inhibitor of activated STAT 3	SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
PIAS4	protein inhibitor of activated STAT 4	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint

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