CLU - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
DYRK1A	dual specificity tyrosine phosphorylation regulated kinase 1A	G0 and Early G1	N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
ELN	elastin	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Rofecoxib	Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
EPPIN	epididymal peptidase inhibitor	Antimicrobial peptides
ETS2	ETS proto-oncogene 2, transcription factor	Oncogene Induced Senescence
FOS	Fos proto-oncogene, AP-1 transcription factor subunit	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling NPAS4 regulates expression of target genes Regulation of PD-L1(CD274) transcription	Pseudoephedrine Nandrolone decanoate Nadroparin
GRB2	growth factor receptor bound protein 2	Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK	Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
HSPA13	heat shock protein family A (Hsp70) member 13	Regulation of HSF1-mediated heat shock response	Copper
HSPD1	heat shock protein family D (Hsp60) member 1	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Copper	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
HUNK	hormonally up-regulated Neu-associated kinase
IL24	interleukin 24	Interleukin-20 family signaling
KATNA1	katanin catalytic subunit A1
KEAP1	kelch like ECH associated protein 1	Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation	Dimethyl fumarate
KLF11	KLF transcription factor 11			Maturity onset diabetes of the young (MODY)
KNSTRN	kinetochore localized astrin (SPAG5) binding protein
LCOR	ligand dependent nuclear receptor corepressor
LEP	leptin	Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin
LEPR	leptin receptor		Leptin Metreleptin
LIG4	DNA ligase 4	2-LTR circle formation Nonhomologous End-Joining (NHEJ)		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
LRP1	LDL receptor related protein 1	Scavenging of heme from plasma Retinoid metabolism and transport	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
LRP2	LDL receptor related protein 2	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Urokinase Insulin human	Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome

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