Search Results for: BRD4

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
H4C16 H4 histone 16
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Cleavage of the damaged purine
  • Cleavage of the damaged purine
  • Meiotic synapsis
  • Packaging Of Telomere Ends
  • Pre-NOTCH Transcription and Translation
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • PRC2 methylates histones and DNA
  • Condensation of Prophase Chromosomes
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • DNA Damage/Telomere Stress Induced Senescence
  • HDACs deacetylate histones
  • PKMTs methylate histone lysines
  • HDMs demethylate histones
  • HATs acetylate histones
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • SIRT1 negatively regulates rRNA expression
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
  • NoRC negatively regulates rRNA expression
  • NoRC negatively regulates rRNA expression
  • SUMOylation of chromatin organization proteins
  • B-WICH complex positively regulates rRNA expression
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • Deposition of new CENPA-containing nucleosomes at the centromere
  • Assembly of the ORC complex at the origin of replication
  • G2/M DNA damage checkpoint
  • RNA Polymerase I Promoter Opening
  • RNA Polymerase I Promoter Escape
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Estrogen-dependent gene expression
  • Meiotic recombination
  • HCMV Early Events
  • HCMV Late Events
  • Transcriptional regulation of granulopoiesis
  • Inhibition of DNA recombination at telomere
  • Defective pyroptosis
  • Negative Regulation of CDH1 Gene Transcription
  • Amyloid fiber formation
  • Chromatin modifications during the maternal to zygotic transition (MZT)
  • Replacement of protamines by nucleosomes in the male pronucleus
  • MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
  • MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
  • Regulation of endogenous retroelements by KRAB-ZFP proteins
  • Regulation of endogenous retroelements by KRAB-ZFP proteins
  • Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
  • Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
  • Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
  • Regulation of PD-L1(CD274) transcription
MESD mesoderm development LRP chaperone
PRPF40A pre-mRNA processing factor 40A
  • mRNA Splicing - Major Pathway
RFC1 replication factor C subunit 1
  • Translesion synthesis by REV1
  • Recognition of DNA damage by PCNA-containing replication complex
  • Translesion Synthesis by POLH
  • Polymerase switching on the C-strand of the telomere
  • PCNA-Dependent Long Patch Base Excision Repair
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Polymerase switching
RFC4 replication factor C subunit 4
  • Translesion synthesis by REV1
  • Recognition of DNA damage by PCNA-containing replication complex
  • Translesion Synthesis by POLH
  • Polymerase switching on the C-strand of the telomere
  • Activation of ATR in response to replication stress
  • PCNA-Dependent Long Patch Base Excision Repair
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
  • Termination of translesion DNA synthesis
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Regulation of TP53 Activity through Phosphorylation
  • Polymerase switching
  • G2/M DNA damage checkpoint
  • Impaired BRCA2 binding to RAD51
TRIM55 tripartite motif containing 55
TRIM63 tripartite motif containing 63
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • Antigen processing: Ubiquitination & Proteasome degradation
USP17L2 ubiquitin specific peptidase 17 like family member 2
  • Ub-specific processing proteases
  • RAS processing
VHL von Hippel-Lindau tumor suppressor
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • SUMOylation of ubiquitinylation proteins
  • Neddylation
  • Replication of the SARS-CoV-1 genome
  • Replication of the SARS-CoV-2 genome
  • RHOBTB3 ATPase cycle
  • Antigen processing: Ubiquitination & Proteasome degradation
  • von Hippel-Lindau syndrome
  • Congenital polycythemia; Familial erythrocytosis (ECYT)
  • Renal cell carcinoma

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