AP2M1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CD22	CD22 molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox
CD2BP2	CD2 cytoplasmic tail binding protein 2
CD3D	CD3 delta subunit of T-cell receptor complex	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Muromonab Blinatumomab Teclistamab Odronextamab	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
CDK11B	cyclin dependent kinase 11B	Recruitment of mitotic centrosome proteins and complexes
CEBPA	CCAAT enhancer binding protein alpha	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis		Acute myeloid leukemia (AML)
CLK2	CDC like kinase 2		Fostamatinib
CORO7	coronin 7
CSNK2B	casein kinase 2 beta	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	ATP Quercetin
CTLA4	cytotoxic T-lymphocyte associated protein 4	Co-stimulation by CD28 Co-inhibition by CTLA4 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Abatacept Ipilimumab Tremelimumab	Graves' disease Allograft rejection Type I diabetes mellitus Hashimoto's thyroiditis
CXorf51A	chromosome X open reading frame 51A
CXorf51B	chromosome X open reading frame 51B
DAB2	DAB adaptor protein 2	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
DCX	doublecortin	Neurofascin interactions		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
DPPA2	developmental pluripotency associated 2	Zygotic genome activation (ZGA)
DVL2	dishevelled segment polarity protein 2	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
EHD2	EH domain containing 2	Factors involved in megakaryocyte development and platelet production
EIF1AD	eukaryotic translation initiation factor 1A domain containing
FAM90A1	family with sequence similarity 90 member A1
FURIN	furin, paired basic amino acid cleaving enzyme	Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Induction of Cell-Cell Fusion Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry Maturation of hRSV A proteins	Capric acid

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