|
|
CTNNA3 |
catenin alpha 3 |
|
|
|
|
|
DVL2 |
dishevelled segment polarity protein 2 |
- TCF dependent signaling in response to WNT
- WNT mediated activation of DVL
- Signaling by Hippo
- PCP/CE pathway
- PCP/CE pathway
- Asymmetric localization of PCP proteins
- Degradation of DVL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT5A-dependent internalization of FZD4
- Negative regulation of TCF-dependent signaling by DVL-interacting proteins
- RHO GTPases Activate Formins
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- WNT5:FZD7-mediated leishmania damping
- WNT5:FZD7-mediated leishmania damping
|
|
|
|
|
FAM90A1 |
family with sequence similarity 90 member A1 |
|
|
|
|
|
FMR1 |
fragile X messenger ribonucleoprotein 1 |
|
|
- Premature ovarian failure
- Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
|
|
|
FNBP1 |
formin binding protein 1 |
- Clathrin-mediated endocytosis
- CDC42 GTPase cycle
- RHOQ GTPase cycle
- RHOJ GTPase cycle
- RND2 GTPase cycle
|
|
|
|
|
FXR2 |
FMR1 autosomal homolog 2 |
|
|
|
|
|
GLIS2 |
GLIS family zinc finger 2 |
|
|
- Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
|
|
|
GPC4 |
glypican 4 |
- Glycosaminoglycan-protein linkage region biosynthesis
- HS-GAG biosynthesis
- HS-GAG biosynthesis
- HS-GAG degradation
- Defective B4GALT7 causes EDS, progeroid type
- Defective B3GAT3 causes JDSSDHD
- Defective EXT2 causes exostoses 2
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- Defective B3GALT6 causes EDSP2 and SEMDJL1
- Attachment and Entry
- Attachment and Entry
- Retinoid metabolism and transport
- Respiratory syncytial virus (RSV) attachment and entry
- RSV-host interactions
|
|
|
|
|
GRIN1 |
glutamate ionotropic receptor NMDA type subunit 1 |
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- Unblocking of NMDA receptors, glutamate binding and activation
- Unblocking of NMDA receptors, glutamate binding and activation
- Ras activation upon Ca2+ influx through NMDA receptor
- RAF/MAP kinase cascade
- Neurexins and neuroligins
- Synaptic adhesion-like molecules
- Assembly and cell surface presentation of NMDA receptors
- Assembly and cell surface presentation of NMDA receptors
- Negative regulation of NMDA receptor-mediated neuronal transmission
- Long-term potentiation
|
- Glutamic acid
- Tramadol
- Enflurane
- Atomoxetine
- Pentobarbital
- Methadone
- Secobarbital
- Meperidine
- Dextropropoxyphene
- Acamprosate
- Donepezil
- Guaifenesin
- Memantine
- Memantine
- Orphenadrine
- Phenobarbital
- Aripiprazole
- Prasterone
- 5,7-Dichlorokynurenic acid
- D-Serine
- Cycloleucine
- Milnacipran
- CNS-5161
- Acetylcysteine
- Ketobemidone
- Gavestinel
- Agmatine
- Ifenprodil
- Magnesium acetate tetrahydrate
- Magnesium carbonate
- Esketamine
- Fluciclovine (18F)
|
|
|
|
GTSE1 |
G2 and S-phase expressed 1 |
- G2/M Checkpoints
- The role of GTSE1 in G2/M progression after G2 checkpoint
|
|
|
|
|
HDDC3 |
HD domain containing 3 |
|
|
|
|
|
HNRNPM |
heterogeneous nuclear ribonucleoprotein M |
- FGFR2 alternative splicing
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
|
|
|
|
|
IKZF3 |
IKAROS family zinc finger 3 |
|
|
|
|
|
KCNQ1 |
potassium voltage-gated channel subfamily Q member 1 |
- Voltage gated Potassium channels
- Phase 3 - rapid repolarisation
- Phase 2 - plateau phase
|
- Enflurane
- Promethazine
- Miconazole
- Bepridil
- Dronedarone
- Azimilide
- ICA-105665
- Isavuconazole
|
- Short QT syndrome
- Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
- Atrial fibrillation
- Type II diabetes mellitus
|
|
|
KDM1A |
lysine demethylase 1A |
- HDACs deacetylate histones
- HDMs demethylate histones
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- Potential therapeutics for SARS
- Negative Regulation of CDH1 Gene Transcription
- Factors involved in megakaryocyte development and platelet production
|
|
|
|
|
KIF19 |
kinesin family member 19 |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
|
|
|
|
|
KLC4 |
kinesin light chain 4 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
|
|
|
|
|
LMO1 |
LIM domain only 1 |
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
|
|
|
|
|
MAGEA6 |
MAGE family member A6 |
|
|
|
|
|
MAGED1 |
MAGE family member D1 |
- NRAGE signals death through JNK
- Caspase activation via Dependence Receptors in the absence of ligand
|
|
|