AKAP8L - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CSTF2	cleavage stimulation factor subunit 2	tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
CSTF2T	cleavage stimulation factor subunit 2 tau variant	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
DGCR6	DiGeorge syndrome critical region gene 6
DHX9	DExH-box helicase 9	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling
DMRT3	doublesex and mab-3 related transcription factor 3
DSCR9	Down syndrome critical region 9
EMD	emerin	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane		Emery-Dreifuss muscular dystrophy
ENKD1	enkurin domain containing 1
FOXD4	forkhead box D4
GPANK1	G-patch domain and ankyrin repeats 1
GPS2	G protein pathway suppressor 2	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
HEMK1	HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Citric acid
HSF4	heat shock transcription factor 4
HUNK	hormonally up-regulated Neu-associated kinase
INCA1	inhibitor of CDK, cyclin A1 interacting protein 1
KPRP	keratinocyte proline rich protein	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
LAGE3	L antigen family member 3	tRNA modification in the nucleus and cytosol
LBR	lamin B receptor	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity		HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
MYOZ1	myozenin 1

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