HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel Novel	Symbols DLG3 and NLGN1	Name 1 discs large MAGUK scaffold protein 3	Name2 neuroligin 1	Pathway 1 Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel Novel	Symbols SUV39H1 and BCL11B	Name 1 SUV39H1 histone lysine methyltransferase	Name2 BCL11 transcription factor B	Pathway 1 PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Pathway 2 Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SUV39H1 and C4orf17	Name 1 SUV39H1 histone lysine methyltransferase	Name2 chromosome 4 open reading frame 17	Pathway 1 PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CTBP2 and LCORL	Name 1 C-terminal binding protein 2	Name2 ligand dependent nuclear receptor corepressor like	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GATA1 and TAF7	Name 1 GATA binding protein 1	Name2 TATA-box binding protein associated factor 7	Pathway 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1 Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Diseases 2
Novel Novel	Symbols TAF1 and TAF5	Name 1 TATA-box binding protein associated factor 1	Name2 TATA-box binding protein associated factor 5	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TAF1 and TAF15	Name 1 TATA-box binding protein associated factor 1	Name2 TATA-box binding protein associated factor 15	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel Novel	Symbols LBR and CBX3	Name 1 lamin B receptor	Name2 chromobox 3	Pathway 1 Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity	Pathway 2 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	Drugs 1	Drugs 2	Diseases 1 HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	Diseases 2
Novel Novel	Symbols ERBB4 and PTPRT	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 protein tyrosine phosphatase receptor type T	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BAX and ERN1	Name 1 BCL2 associated X, apoptosis regulator	Name2 endoplasmic reticulum to nucleus signaling 1	Pathway 1 Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor	Pathway 2 IRE1alpha activates chaperones IRE1alpha activates chaperones	Drugs 1 TAK-901	Drugs 2 N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib	Diseases 1 Colorectal cancer	Diseases 2
Novel Novel	Symbols TAF13 and TBP	Name 1 TATA-box binding protein associated factor 13	Name2 TATA-box binding protein	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel Novel	Symbols PTPN12 and RBM19	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 RNA binding motif protein 19	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP1B1 and AP1G1	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 adaptor related protein complex 1 subunit gamma 1	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP1B1 and RNF39	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 ring finger protein 39	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TLE5 and SUPT5H	Name 1 TLE family member 5, transcriptional modulator	Name2 SPT5 homolog, DSIF elongation factor subunit	Pathway 1 Repression of WNT target genes	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols IL6ST and KCNIP1	Name 1 interleukin 6 cytokine family signal transducer	Name2 potassium voltage-gated channel interacting protein 1	Pathway 1 Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Pathway 2 Phase 1 - inactivation of fast Na+ channels	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ATXN1 and FAT4	Name 1 ataxin 1	Name2 FAT atypical cadherin 4	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2
Novel Novel	Symbols ATXN1 and LITAF	Name 1 ataxin 1	Name2 lipopolysaccharide induced TNF factor	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2
Novel Novel	Symbols ATXN1 and FAR1	Name 1 ataxin 1	Name2 fatty acyl-CoA reductase 1	Pathway 1	Pathway 2 Wax biosynthesis	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2
Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel	Symbols DLG3 and NLGN1	Name 1 discs large MAGUK scaffold protein 3	Name2 neuroligin 1	Pathway 1 Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel	Symbols SUV39H1 and BCL11B	Name 1 SUV39H1 histone lysine methyltransferase	Name2 BCL11 transcription factor B	Pathway 1 PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Pathway 2 Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SUV39H1 and C4orf17	Name 1 SUV39H1 histone lysine methyltransferase	Name2 chromosome 4 open reading frame 17	Pathway 1 PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTBP2 and LCORL	Name 1 C-terminal binding protein 2	Name2 ligand dependent nuclear receptor corepressor like	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GATA1 and TAF7	Name 1 GATA binding protein 1	Name2 TATA-box binding protein associated factor 7	Pathway 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1 Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Diseases 2
Novel	Symbols TAF1 and TAF5	Name 1 TATA-box binding protein associated factor 1	Name2 TATA-box binding protein associated factor 5	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TAF1 and TAF15	Name 1 TATA-box binding protein associated factor 1	Name2 TATA-box binding protein associated factor 15	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel	Symbols LBR and CBX3	Name 1 lamin B receptor	Name2 chromobox 3	Pathway 1 Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity	Pathway 2 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	Drugs 1	Drugs 2	Diseases 1 HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	Diseases 2
Novel	Symbols ERBB4 and PTPRT	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 protein tyrosine phosphatase receptor type T	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BAX and ERN1	Name 1 BCL2 associated X, apoptosis regulator	Name2 endoplasmic reticulum to nucleus signaling 1	Pathway 1 Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor	Pathway 2 IRE1alpha activates chaperones IRE1alpha activates chaperones	Drugs 1 TAK-901	Drugs 2 N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib	Diseases 1 Colorectal cancer	Diseases 2
Novel	Symbols TAF13 and TBP	Name 1 TATA-box binding protein associated factor 13	Name2 TATA-box binding protein	Pathway 1 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel	Symbols PTPN12 and RBM19	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 RNA binding motif protein 19	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP1B1 and AP1G1	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 adaptor related protein complex 1 subunit gamma 1	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP1B1 and RNF39	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 ring finger protein 39	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TLE5 and SUPT5H	Name 1 TLE family member 5, transcriptional modulator	Name2 SPT5 homolog, DSIF elongation factor subunit	Pathway 1 Repression of WNT target genes	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols IL6ST and KCNIP1	Name 1 interleukin 6 cytokine family signal transducer	Name2 potassium voltage-gated channel interacting protein 1	Pathway 1 Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Pathway 2 Phase 1 - inactivation of fast Na+ channels	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ATXN1 and FAT4	Name 1 ataxin 1	Name2 FAT atypical cadherin 4	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2
Novel	Symbols ATXN1 and LITAF	Name 1 ataxin 1	Name2 lipopolysaccharide induced TNF factor	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2
Novel	Symbols ATXN1 and FAR1	Name 1 ataxin 1	Name2 fatty acyl-CoA reductase 1	Pathway 1	Pathway 2 Wax biosynthesis	Drugs 1	Drugs 2	Diseases 1 Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Diseases 2

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