JPH4 and KCNN4

Number of citations: 0 (PubMedID 31461656)
Data Source: BioGRID (fluorescent resonance energy transfer)

		JPH4	KCNN4
Name		junctophilin 4	potassium calcium-activated channel subfamily N member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Junctional Membrane Complex Dendritic Shaft	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Vesicle Ruffle Membrane Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity Protein Homodimerization Activity
	Biological Process	Regulation Of Cytokine Production Learning Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Synaptic Plasticity Neuromuscular Process Controlling Balance Calcium Ion Transport Into Cytosol Regulation Of Store-operated Calcium Entry	Immune System Process Monoatomic Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Monoatomic Ion Transmembrane Transport Macropinocytosis Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Transport Protein Homotetramerization Establishment Of Localization In Cell Regulation Of Biological Quality Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		None	Ca2+ activated K+ channels
Drugs		None	Clotrimazole Quinine Procaine Ritodrine Nitrendipine Miconazole Halothane Colforsin Trimebutine
GWAS		No GWAS studies recorded	Breast cancer ( 23535729 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494 ) Mean corpuscular volume ( 27863252 29403010 32888494 ) Mean platelet volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		6 interacting genes: BCL2L13 CACNA1D KCNN4 RYR2 UBQLN1 UBQLN2	13 interacting genes: BIK CACNA1D CALM1 CNIH3 FXYD3 GPR152 JPH3 JPH4 PMP22 PRKAG1 RYR2 SLC30A2 STX1B
Entrez ID		84502	3783
HPRD ID		17170	04130
Ensembl ID		ENSG00000092051	ENSG00000104783
Uniprot IDs		Q96JJ6	O15554
PDB IDs		Not available	6CNM 6CNN 6CNO 6D42
GO Terms Enriched among Interactors		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Transport Calcium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagy Regulation Of Potassium Ion Transmembrane Transport Calcium Channel Activity Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Intermediate Conductance Calcium-activated Potassium Channel Activity Autophagosome Negative Regulation Of Store-operated Calcium Channel Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Regulation Of Heart Rate Autophagosome Organization Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Suramin Binding Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Z Disc Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Stabilization Of Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Type B Pancreatic Cell Apoptotic Process Regulation Of AV Node Cell Action Potential Left Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Inorganic Ion Transmembrane Transport Macroautophagy Monoatomic Ion Channel Activity Small Conductance Calcium-activated Potassium Channel Activity	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Metal Ion Transport Calcium Ion Transport Into Cytosol Regulation Of Heart Contraction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Regulation Of Striated Muscle Contraction Regulation Of Blood Circulation Regulation Of System Process Metal Ion Transport Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium Ion Transmembrane Transport Regulation Of Transport Inorganic Ion Transmembrane Transport Calcium-mediated Signaling Membrane Regulation Of Muscle Contraction Junctional Membrane Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Membrane Potential Plasma Membrane Calcium Ion Transport Monoatomic Ion Transport Regulation Of Muscle System Process Detection Of Calcium Ion Inorganic Cation Transmembrane Transport Regulation Of Heart Rate Monoatomic Cation Transmembrane Transport Transmembrane Transport Smooth Endoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Cell Action Potential Protein Kinase Binding Cardiac Muscle Cell Action Potential Involved In Contraction Modulation Of Chemical Synaptic Transmission Cardiac Muscle Cell Action Potential Regulation Of Synaptic Plasticity Dendritic Shaft