DENND10P1 and ALDH2

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		DENND10P1	ALDH2
Name		DENND10 pseudogene 1	aldehyde dehydrogenase 2 family member
Structure		No pdb structure
GO Annotations	Cellular Component	None	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	None	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Phenylacetaldehyde Dehydrogenase (NAD+) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NAD Binding Carboxylesterase Activity
	Biological Process	None	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Metabolic Process Ethanol Catabolic Process Nitroglycerin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Regulation Of Dopamine Biosynthetic Process Regulation Of Serotonin Biosynthetic Process
Pathways		None	Metabolism of serotonin Smooth Muscle Contraction Ethanol oxidation Mitochondrial protein degradation
Drugs		None	NADH Guanidine Disulfiram Daidzin Crotonaldehyde
Diseases		None	Acute alcohol sensitivity
GWAS		No GWAS studies recorded	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404 ) Alcohol consumption (drinks per week) ( 31959922 ) Alcohol consumption (max-drinks) ( 29460428 24277619 ) Alcohol dependence ( 24277619 ) Alcohol dependence symptom count ( 29460428 ) Alcohol drinking status (current drinker vs non-current drinker) ( 34073884 ) Aspartate aminotransferase levels ( 30718733 ) Blood pressure ( 21572416 ) Body mass index ( 26426971 24861553 28892062 ) Coffee consumption ( 31959922 29367735 ) Confectionary intake ( 33632354 ) Coronary artery disease ( 30402224 33020668 ) Coronary heart disease ( 23364394 21971053 ) Crohn's disease ( 28067908 26192919 ) Diastolic blood pressure ( 25249183 26390057 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Drinking behavior ( 21372407 23364009 ) Epilepsy ( 33913524 ) Esophageal cancer ( 19698717 ) Estimated glomerular filtration rate ( 31015462 ) Excessive alcohol consumption ( 33093602 ) Fish consumption ( 32895509 ) Fish intake frequency ( 31959922 ) Gamma glutamyl transferase levels ( 33093602 ) Gout ( 32238385 ) Gout (combined type) ( 32238385 ) Gout vs. Hyperuricemia ( 31289104 ) Green tea consumption ( 31959922 ) Height ( 31562340 ) Hematological and biochemical traits ( 20139978 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) Hypertension ( 32709000 25249183 ) Inflammatory bowel disease ( 26192919 28067908 ) Intracranial aneurysm ( 22286173 ) Ischemic stroke ( 26708676 ) Ischemic stroke (small artery occlusion) ( 26708676 ) Mean arterial pressure ( 27618448 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Mean corpuscular hemoglobin concentration ( 20139978 ) Metabolic syndrome ( 28371326 ) Milk consumption ( 31959922 ) Myocardial infarction ( 30226566 24916648 ) Natto consumption ( 31959922 ) Oral cavity and pharyngeal cancer ( 21437268 ) Primary biliary cholangitis ( 26394269 ) Psoriasis ( 25854761 ) Renal function-related traits (sCR) ( 22797727 ) Renal overload gout ( 32238385 ) Renal underexcretion gout ( 32238385 ) Response to alcohol consumption (flushing response) ( 24277619 29460428 ) Serum alpha1-antitrypsin levels ( 26174136 ) Serum uric acid levels ( 29408531 29124443 ) Small vessel stroke (CCSp classification) ( 32047268 ) Smoking behaviour (cigarettes smoked per day) ( 31089300 ) Stroke (ischemic) ( 23041239 ) Sweet taste preference ( 32572145 ) Systolic blood pressure ( 26390057 25249183 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Tea consumption ( 33080986 ) Tofu consumption ( 31959922 ) Triglycerides ( 26582766 22171074 ) Type 2 diabetes ( 32499647 ) Urate levels ( 31578528 ) Waist-to-hip ratio adjusted for BMI ( 34054925 ) Yoghurt consumption ( 31959922 )
Interacting Genes		2 interacting genes: ALDH2 TMEM256	15 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 OGT RPL13A SIRT3 SLC35F6 UNC119
Entrez ID		55855	217
HPRD ID		06592	00003
Ensembl ID		Not available	ENSG00000111275
Uniprot IDs		Not available	A0A384NPN7 P05091
PDB IDs		Not available	1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13 8DR9 8SHS
GO Terms Enriched among Interactors		Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process Aldehyde Dehydrogenase [NAD(P)+] Activity Regulation Of Dopamine Biosynthetic Process Carboxylesterase Activity Ethanol Metabolic Process Aldehyde Catabolic Process Aldehyde Dehydrogenase (NAD+) Activity Cellular Detoxification Of Aldehyde Ethanol Catabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Regulation Of Dopamine Metabolic Process Alcohol Catabolic Process NAD Binding Electron Transfer Activity Aldehyde Metabolic Process Mitochondrion Xenobiotic Metabolic Process Cellular Detoxification Extracellular Exosome	Synapse Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Unfolded Protein Protein-folding Chaperone Binding Apolipoprotein Binding Unfolded Protein Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Component Organization Protein Refolding Aminobutyraldehyde Dehydrogenase (NAD+) Activity 3-deoxyglucosone Dehydrogenase Activity Fructosamine Catabolic Process Acetaldehyde Dehydrogenase (NAD+) Activity Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Folding Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Negative Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Lipid Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Formation Of Translation Preinitiation Complex Regulation Of Phosphorus Metabolic Process Fructosamine Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Cell Junction Assembly Post-transcriptional Regulation Of Gene Expression Clathrin-coated Pit Lipoprotein Particle Mitochondrion Positive Regulation Of Protein Import Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Negative Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Type II Interferon Production