LGI1

Name	leucine rich glioma inactivated 1
Structure
Novel Interactors	1 novel interactors: SLC27A2
Interactors	2 interactors: ADAM22 CLIC6
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Golgi Apparatus Dendrite Synaptic Cleft Axon Initial Segment Synapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways	LGI-ADAM interactions
Diseases	Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)
GWAS	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 29274321 ) Response to (pegylated) interferon in chronic hepatitis B ( 30715261 ) Response to perphenazine in schizophrenia ( 29503163 )
Entrez ID	9211
HPRD ID	05216
Ensembl ID	ENSG00000108231
Uniprot IDs	A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970
PDB IDs	5Y2Z 5Y30 5Y31 8HPY 8HQ1 8HQ2 8Y6B
GO Terms Enriched among Interactors ?	Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding D2 Dopamine Receptor Binding Methyl-branched Fatty Acid Metabolic Process Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Lipid Import Into Cell Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Bile Acid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Bile Acid Metabolic Process Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Chloride Channel Complex