LGI1 and ADAM22

Number of citations of the paper that reports this interaction (PMID 16990550)
60

Data Source:
HPRD (in vitro)

		LGI1	ADAM22
Gene Name		leucine-rich, glioma inactivated 1	ADAM metallopeptidase domain 22
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Junction Synapse	Integral Component Of Membrane Axon
	Molecular Function	Receptor Binding Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding
	Biological Process	Nervous System Development Axon Guidance Cell Proliferation Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Protein Homooligomerization	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ADAM22	5 interactors: EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		9211	53616
HPRD ID		05216	04751
Ensembl ID		ENSG00000108231	ENSG00000008277
Uniprot IDs		O95970	Q08AL8 Q9P0K1
PDB IDs			3G5C
Enriched GO Terms of Interacting Partners?		Myelination In Peripheral Nervous System Schwann Cell Development Schwann Cell Differentiation Glial Cell Development Peripheral Nervous System Development Adult Locomotory Behavior Myelination Axon Ensheathment Adult Behavior Glial Cell Differentiation Negative Regulation Of Cell Adhesion Locomotory Behavior Gliogenesis Single-organism Behavior	Cellular Component Assembly Regulation Of Cellular Component Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Locomotion Regulation Of Signaling Axon Guidance Positive Regulation Of Mitochondrion Organization Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Mitochondrion Organization Chemotaxis Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Organelle Organization Actin Polymerization-dependent Cell Motility Intrinsic Apoptotic Signaling Pathway Neuron Development Platelet Activation Positive Regulation Of Apoptotic Signaling Pathway Golgi Reassembly Ras Protein Signal Transduction Cell Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Neuron Differentiation Cell Projection Organization Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Establishment Of Golgi Localization Exit From Mitosis Positive Regulation Of Signal Transduction Golgi Inheritance Actin Filament Organization Behavioral Response To Ethanol Histamine Secretion Apoptotic Signaling Pathway Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Histamine Transport
Tagcloud ?		4pba abnormally adam22 adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure	4pba abnormally adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		4pba abnormally adam22 adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure