SH2D2A

Name	SH2 domain containing 2A
Structure	No pdb structure
Novel Interactors	1 novel interactors: ZYG11B
Interactors	34 interactors: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding SH3 Domain Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation
Pathways	VEGFA-VEGFR2 Pathway
GWAS	Autoimmune thyroid disease ( 32581359 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Sjögren's syndrome ( 28076899 )
Entrez ID	9047
HPRD ID	05152
Ensembl ID	ENSG00000027869
Uniprot IDs	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction