C9

Name	complement C9
Structure
Interactors	4 interactors: C8A CD59 CLU LAMTOR5
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex
	Molecular Function	Protein Binding
	Biological Process	Cell Killing Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Protein Homooligomerization Complement Activation, GZMK Pathway
Pathways	Terminal pathway of complement Regulation of Complement cascade
Drugs	Copper
Diseases	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS	Advanced age-related macular degeneration ( 26691988 ) Blood protein levels ( 30072576 ) Chronic kidney disease ( 20383146 ) Health literacy ( 31250787 ) Systemic lupus erythematosus ( 19838195 )
Entrez ID	735
HPRD ID	00408
Ensembl ID	ENSG00000113600
Uniprot IDs	P02748
PDB IDs	5FMW 6DLW 6H03 6H04 7NYC 7NYD 8B0G 8B0H 8DE6
GO Terms Enriched among Interactors ?	Complement Activation Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Complement-dependent Cytotoxicity Complement Binding Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Regulation Of Complement Activation Humoral Immune Response Complement Activation, Classical Pathway Protein Sequestering Activity Immune Effector Process Regulation Of Humoral Immune Response Activation Of Immune Response Protein Localization To Lysosome Protein Localization To Vacuole Positive Regulation Of Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Blood Microparticle Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Immune Response Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Immune System Process Negative Regulation Of Immune Response Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Response To Other Organism Positive Regulation Of Inclusion Body Assembly Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Ragulator Complex Immune Response Regulation Of Neurofibrillary Tangle Assembly Membrane Attack Complex Other Organism Cell Membrane Protein Import Response To External Biotic Stimulus Spherical High-density Lipoprotein Particle FNIP-folliculin RagC/D GAP Microglial Cell Proliferation Extracellular Space Protein Carrier Chaperone Protein-containing Complex Binding Complement Activation, GZMK Pathway Regulation Of Immune System Process Transmembrane Transporter Complex Response To Virus Response To Misfolded Protein Negative Regulation Of Amyloid Fibril Formation