UBA7

Name	ubiquitin like modifier activating enzyme 7
Structure
Novel Interactors	1 novel interactors: DNAL4
Interactors	7 interactors: FAS ISG15 LCOR RSPH1 UBE2E1 UBE2L3 UBE2L6
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity ISG15 Activating Enzyme Activity
	Biological Process	DNA Damage Response Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Innate Immune Response
Pathways	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation Modulation of host responses by IFN-stimulated genes
GWAS	Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Menarche (age at onset) ( 25231870 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 21297633 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	7318
HPRD ID	01873
Ensembl ID	ENSG00000182179
Uniprot IDs	P41226
PDB IDs	8OIF 8SE9 8SEA 8SEB 8SV8 8WWX
GO Terms Enriched among Interactors ?	ISG15-protein Conjugation Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Ubiquitin-like Protein Transferase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Macromolecule Catabolic Process Fas Signaling Pathway Ubiquitin Ligase Complex Proteolysis Radial Spoke Head 1 Radial Spoke Head 3 Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Response To Hyperoxia Radial Spoke Head CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Outer Dense Fiber Regulation Of Protein Ubiquitination Necroptotic Signaling Pathway Protein Modification Process Ubiquitin-protein Transferase Activator Activity