SIM1

Name	SIM bHLH transcription factor 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: FOXO3
Interactors	3 interactors: ARNT ARNT2 HSP90AA1
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Ureteric Bud Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation System Development
GWAS	Body size at age 10 ( 32376654 ) Creatinine levels ( 29403010 ) Erectile dysfunction ( 30297428 ) Estimated glomerular filtration rate ( 31152163 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gait speed in old age ( 28077804 ) Glomerular filtration rate ( 29403010 ) Iris color (L* coordinate) ( 30895295 ) Irritable mood ( 29500382 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Major depressive disorder ( 27479909 ) Menarche (age at onset) ( 25231870 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Sociability score ( 34054130 ) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971 )
Entrez ID	6492
HPRD ID	07049
Ensembl ID	ENSG00000112246
Uniprot IDs	P81133
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Positive Regulation Of Erythrocyte Differentiation Response To Hypoxia Response To Decreased Oxygen Levels Response To Oxygen Levels Regulation Of Erythrocyte Differentiation Positive Regulation Of Catabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Factor Activity CTP Binding DATP Binding Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Muscle Atrophy Initiation Of Primordial Ovarian Follicle Growth Cellular Response To Corticosterone Stimulus Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Dimerization Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Water-immersion Restraint Stress Rho GDP-dissociation Inhibitor Binding Regulation Of Myeloid Cell Differentiation Chromatin Cellular Response To Oxidative Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Mitochondrial Transcription Factor Activity Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Post-translational Protein Modification Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Sperm Mitochondrial Sheath Regulation Of Muscle System Process Telomerase Holoenzyme Complex Assembly Cellular Response To Chemical Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance RNA Polymerase II Transcription Repressor Complex Response To Xenobiotic Stimulus Mitochondrial Transcription Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity