TMPRSS3

Name	transmembrane serine protease 3
Structure	No pdb structure
Interactors	3 interactors: EEF1A1 RXRA TMED7
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Sodium Channel Regulator Activity
	Biological Process	Proteolysis Intracellular Sodium Ion Homeostasis Sensory Perception Of Sound
Diseases	Deafness, autosomal recessive
GWAS	Age-related hearing impairment ( 34108613 ) Face memory ( 31596458 )
Entrez ID	64699
HPRD ID	05696
Ensembl ID	ENSG00000160183
Uniprot IDs	P57727
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Vitamin D Response Element Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding LBD Domain Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Chaperone-mediated Autophagy Kinase Activator Activity Host-mediated Perturbation Of Viral Genome Replication Cytoplasmic Side Of Lysosomal Membrane Host-mediated Activation Of Viral Genome Replication Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Vitamin D Receptor Signaling Pathway COPI Vesicle Coat Nuclear Vitamin D Receptor Binding COPI-coated Vesicle Membrane COPII Vesicle Coat Translation Elongation Factor Activity Monocyte Differentiation Retinoic Acid Binding Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Host-mediated Activation Of Viral Process Cellular Response To Lipoprotein Particle Stimulus Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Response To Nutrient Levels Cellular Response To Low-density Lipoprotein Particle Stimulus Peptide Binding Positive Regulation Of Cholesterol Transport COPII-coated ER To Golgi Transport Vesicle Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Cellular Response To Epidermal Growth Factor Stimulus MRNA Transcription By RNA Polymerase II Regulation Of Cholesterol Efflux