TMPRSS3 and TMED7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMPRSS3	TMED7
Description		transmembrane serine protease 3	transmembrane p24 trafficking protein 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane COPI Vesicle Coat COPII Vesicle Coat Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Sodium Channel Regulator Activity	Protein Binding
	Biological Process	Proteolysis Intracellular Sodium Ion Homeostasis Sensory Perception Of Sound	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases		Deafness, autosomal recessive
GWAS		Age-related hearing impairment ( 34108613) Face memory ( 31596458)	Hip circumference adjusted for BMI ( 34021172) Liver injury in combined anti-retroviral and anti-tuberculosis drug-treated HIV with tuberculosis ( 28388302) Response to antidepressants (symptom improvement) ( 29160301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: EEF1A1 RXRA TMED7	1 interacting genes: TMPRSS3
Entrez ID		64699	51014
HPRD ID		05696	13029
Ensembl ID		ENSG00000160183	ENSG00000134970
Uniprot IDs		P57727	Q9Y3B3
PDB IDs
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Vitamin D Response Element Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding LBD Domain Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Chaperone-mediated Autophagy Kinase Activator Activity Host-mediated Perturbation Of Viral Genome Replication Cytoplasmic Side Of Lysosomal Membrane Host-mediated Activation Of Viral Genome Replication Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Vitamin D Receptor Signaling Pathway COPI Vesicle Coat Nuclear Vitamin D Receptor Binding COPI-coated Vesicle Membrane COPII Vesicle Coat Translation Elongation Factor Activity Monocyte Differentiation Retinoic Acid Binding Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Host-mediated Activation Of Viral Process Cellular Response To Lipoprotein Particle Stimulus Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Response To Nutrient Levels Cellular Response To Low-density Lipoprotein Particle Stimulus Peptide Binding Positive Regulation Of Cholesterol Transport COPII-coated ER To Golgi Transport Vesicle Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Cellular Response To Epidermal Growth Factor Stimulus MRNA Transcription By RNA Polymerase II Regulation Of Cholesterol Efflux	RNA Exonuclease Activity, Producing 5'-phosphomonoesters Intracellular Sodium Ion Homeostasis Telomerase RNA Binding MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity 5'-3' RNA Exonuclease Activity Regulation Of Telomerase RNA Localization To Cajal Body RNA Decapping Histone MRNA Metabolic Process Sodium Ion Homeostasis Sodium Channel Regulator Activity Negative Regulation Of Telomere Maintenance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Manganese Ion Binding Hydrolase Activity Negative Regulation Of Chromosome Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Biosynthetic Process RISC Complex MRNA Destabilization P-body RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Regulation Of Telomere Maintenance Positive Regulation Of MRNA Catabolic Process
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