SHB

Name	SH2 domain containing adaptor protein B
Structure	No pdb structure
Novel Interactors	1 novel interactors: FGFR1
Interactors	27 interactors: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Angiogenesis Blood Vessel Development Apoptotic Process Signal Transduction Hemopoiesis Cell Differentiation B Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Blood Vessel Morphogenesis T Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Negative Regulation Of Oocyte Maturation
Pathways	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
GWAS	Brain structure ( 20171287 ) Chronotype ( 30696823 ) Loneliness (linear analysis) ( 27629369 ) Longevity (100 years and older) ( 33948810 ) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Type 2 diabetes (age of onset) ( 28060188 )
Entrez ID	6461
HPRD ID	02635
Ensembl ID	ENSG00000107338
Uniprot IDs	Q15464
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of MAPK Cascade Receptor Complex Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Plasma Membrane ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Cell Activation Intracellular Signaling Cassette Cell Migration Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Leukocyte Activation Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphorylation Cell Motility Cellular Developmental Process Phosphorylation ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process T Cell Activation Positive Regulation Of Epithelial Cell Proliferation