SDHA

Name	succinate dehydrogenase complex flavoprotein subunit A
Structure
Interactors	10 interactors: CDC42 CFTR CSNK2B DSCAM ERCC6 HSPB2 LCOR RSPH1 WBP2 XIAP
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Nervous System Development Electron Transport Chain Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Carboxin Thenoyltrifluoroacetone Ubiquinone Q1 Ubidecarenone
Diseases	Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	Hip circumference adjusted for BMI ( 34021172 )
Entrez ID	6389
HPRD ID	02914
Ensembl ID	ENSG00000073578
Uniprot IDs	D6RFM5 P31040
PDB IDs	6VAX 8DYD 8DYE 8GS8