CFB

Name	complement factor B
Structure
Novel Interactors	1 novel interactors: NOMO1
Interactors	6 interactors: C3 CFP HSP90AA1 LAMC3 LAMTOR5 RPA2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Complement Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Activation Of Membrane Attack Complex Pre-B Cell Differentiation Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Response To Bacterium Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs	Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate
Diseases	Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS	A body shape index ( 34021172 ) Advanced age-related macular degeneration ( 26691988 ) Age-related macular degeneration ( 20385826 23577725 23455636 20385819 22694956 21665990 ) Age-related macular degeneration (choroidal neovascularisation) ( 22705344 ) Age-related macular degeneration (extreme sampling) ( 23577725 ) Age-related macular degeneration (geographic atrophy) ( 22705344 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic hepatitis B infection ( 25802187 ) Coronary artery disease ( 29212778 ) Disease progression in age-related macular degeneration ( 29346644 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Hematology traits ( 23263863 ) Inflammatory bowel disease ( 28067908 ) Neutrophil percentage of white cells ( 32888494 ) Prostate cancer ( 23535732 ) Rosacea symptom severity ( 29771307 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 28067908 24837172 )
Entrez ID	629
HPRD ID	00718
Ensembl ID	ENSG00000243649
Uniprot IDs	A0A1U9X7H8 P00751
PDB IDs	1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W 7JTN 7JTQ 7NOZ 8ENU 8EOK 8UIN
GO Terms Enriched among Interactors ?	Positive Regulation Of Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Phagocytosis Positive Regulation Of Activation Of Membrane Attack Complex Response To Other Organism Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Positive Regulation Of Defense Response Activation Of Immune Response Telomere Maintenance Protein Phosphatase Binding CTP Binding Regulation Of Cell Size DATP Binding Neurofibrillary Tangle Assembly UTP Binding Positive Regulation Of Protein Localization To Nucleus Sulfonylurea Receptor Binding Positive Regulation Of Complement Activation, Alternative Pathway Cytoplasmic Side Of Golgi Membrane Response To External Biotic Stimulus Secretory Granule Lumen Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Rho GDP-dissociation Inhibitor Binding Telomere Organization Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Complement-mediated Synapse Pruning Protein Localization To Organelle Negative Regulation Of Nodal Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune Response Positive Regulation Of Endocytosis Sperm Mitochondrial Sheath Regulation Of Complement Activation, Alternative Pathway Ragulator Complex Telomerase Holoenzyme Complex Assembly Regulation Of Cytokine Production Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Protein-containing Complex Positive Regulation Of Apoptotic Cell Clearance Chaperone-mediated Autophagy