BDH1

Name	3-hydroxybutyrate dehydrogenase 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: GCH1
Interactors	1 interactors: APP
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Intracellular Membrane-bounded Organelle Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Catalytic Activity 3-hydroxybutyrate Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process
Pathways	Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation
Drugs	NADH
GWAS	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309 ) Frontotemporal dementia with GRN mutation ( 29724592 ) Waist-hip ratio ( 28552196 )
Entrez ID	622
HPRD ID	04344
Ensembl ID	ENSG00000161267
Uniprot IDs	A0A384MTY4 E9PCG9 Q02338
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process GTP Cyclohydrolase I Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Blood Circulation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Nitric-oxide Synthase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Lung Blood Pressure Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Removal Of Superoxide Radicals Axon Choice Point Recognition Tetrahydrofolate Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Tetrahydrobiopterin Biosynthetic Process Peptidase Activator Activity Response To Cytokine Regulation Of System Process Cellular Response To Manganese Ion Regulation Of Cellular Response To Stress Heparan Sulfate Binding Signaling Receptor Activator Activity Folic Acid-containing Compound Biosynthetic Process