BDH1 and GCH1

		BDH1	GCH1
Description		3-hydroxybutyrate dehydrogenase 1	GTP cyclohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Intracellular Membrane-bounded Organelle Matrix Side Of Mitochondrial Inner Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Catalytic Activity 3-hydroxybutyrate Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals
Pathways		Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		NADH	Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Frontotemporal dementia with GRN mutation ( 29724592) Waist-hip ratio ( 28552196)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		1 interacting genes: APP	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		622	2643
HPRD ID		04344	02573
Ensembl ID		ENSG00000161267	ENSG00000131979
Uniprot IDs		A0A384MTY4 E9PCG9 Q02338	P30793 Q8IZH9
PDB IDs			1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process GTP Cyclohydrolase I Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Blood Circulation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Nitric-oxide Synthase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Lung Blood Pressure Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Removal Of Superoxide Radicals Axon Choice Point Recognition Tetrahydrofolate Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Tetrahydrobiopterin Biosynthetic Process Peptidase Activator Activity Response To Cytokine Regulation Of System Process Cellular Response To Manganese Ion Regulation Of Cellular Response To Stress Heparan Sulfate Binding Signaling Receptor Activator Activity Folic Acid-containing Compound Biosynthetic Process	Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding
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