BCL9

Name	BCL9 transcription coactivator
Structure
Interactors	6 interactors: BCL2L13 CTNNB1 MAP1LC3A PYGO1 PYGO2 USP9X
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cis-Golgi Network Sarcoplasm Beta-catenin-TCF Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
GWAS	Adult body size ( 32376654 ) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145 ) Schizophrenia (negative symptoms) ( 23382809 ) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Type 2 diabetes ( 25760438 )
Entrez ID	607
HPRD ID	04000
Ensembl ID	ENSG00000116128
Uniprot IDs	O00512 Q1JQ81
PDB IDs	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9 8Y0P
GO Terms Enriched among Interactors ?	Canonical Wnt Signaling Pathway Spermatid Nucleus Differentiation Beta-catenin-TCF Complex Kidney Development Germ Cell Development Wnt Signaling Pathway Mitophagy Developmental Growth Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Reproductive Process Neuron Projection Extension Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Developmental Cell Growth Organelle Organization K11-linked Deubiquitinase Activity Autophagy Of Mitochondrion Nucleus Organization Spermatid Development Histone Acetyltransferase Regulator Activity Oviduct Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Fungiform Papilla Formation Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Centriole-centriole Cohesion Embryonic Skeletal Limb Joint Morphogenesis Lung Induction Neuron Migration Catenin-TCF7L2 Complex Developmental Growth Involved In Morphogenesis Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Glial Cell-neuron Signaling