RECQL

Name	RecQ like helicase
Structure
Novel Interactors	3 novel interactors: MARK3 NKX2-2 PLEKHA5
Interactors	8 interactors: CEBPA E2F4 KPNA2 KPNA4 LINC00632 NEIL3 RPA1 UBC
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity Metal Ion Binding DNA/DNA Annealing Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Replication Fork Processing
GWAS	Blood protein levels ( 30072576 )
Entrez ID	5965
HPRD ID	02762
Ensembl ID	ENSG00000004700
Uniprot IDs	P46063
PDB IDs	2V1X 2WWY 4U7D 6JTZ 8YRS
GO Terms Enriched among Interactors ?	NLS-dependent Protein Nuclear Import Complex Nucleoplasm NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Hippo Signaling Male Germ Cell Nucleus Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment MCM Complex Binding Damaged DNA Binding Response To Vitamin B2 C/EBP Complex Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Cell Development Chromatin Binding CHOP-C/EBP Complex Histone Deacetylase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific White Fat Cell Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Epithelial Cell Development Import Into Nucleus Protein Import Into Nucleus Viral Penetration Into Host Nucleus Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Spinal Cord Oligodendrocyte Cell Fate Specification Single-stranded Telomeric DNA Binding Single-stranded DNA Binding Depurination