RDH5

Name	retinol dehydrogenase 5
Structure	No pdb structure
Novel Interactors	2 novel interactors: FDX1 NAB2
Interactors	3 interactors: ORC4 RGR RLBP1
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process
Pathways	The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function
Drugs	NADH Vitamin A
Diseases	Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS	Advanced age-related macular degeneration ( 26691988 ) High myopia ( 31816047 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 23396134 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )
Entrez ID	5959
HPRD ID	03370
Ensembl ID	ENSG00000135437
Uniprot IDs	Q92781
PDB IDs	Not available
GO Terms Enriched among Interactors ?	P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin