NLN

Name	neurolysin
Structure
Novel Interactors	1 novel interactors: CWC27
Interactors	2 interactors: APP NTS
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Plasma Membrane
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Peptide Binding Metal Ion Binding
	Biological Process	Regulation Of Gluconeogenesis Proteolysis Peptide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Fiber Differentiation
Pathways	Peptide ligand-binding receptors
GWAS	Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Cortical surface area (MOSTest) ( 32665545 ) ghrelin levels ( 33852427 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Refractive astigmatism ( 25367360 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	57486
HPRD ID	07495
Ensembl ID	ENSG00000123213
Uniprot IDs	Q9BYT8
PDB IDs	5LUZ 5LV0 8VJU 8VJV 8VJW 8VJX 8VJY
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuropeptide Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding