NLN and CWC27

		NLN	CWC27
Description		neurolysin	CWC27 spliceosome associated cyclophilin
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Plasma Membrane	Nucleus Nucleoplasm U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Peptide Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Regulation Of Gluconeogenesis Proteolysis Peptide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Fiber Differentiation	MRNA Splicing, Via Spliceosome Protein Folding
Pathways		Peptide ligand-binding receptors	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (MOSTest) ( 32665545) ghrelin levels ( 33852427) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Refractive astigmatism ( 25367360) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Bladder cancer ( 27206850) Central corneal thickness ( 29760442 31798171) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Obesity-related traits ( 23251661) Refractive error ( 32231278) Systolic blood pressure ( 30224653) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		2 interacting genes: APP NTS	5 interacting genes: CLK1 FRA10AC1 HMGA1 MORF4L1 OGT
Entrez ID		57486	10283
HPRD ID		07495	11541
Ensembl ID		ENSG00000123213	ENSG00000153015
Uniprot IDs		Q9BYT8	A0A8I5KQK1 A0A8I5KRF5 A0A8I5KUW8 D6REK3 Q6UX04
PDB IDs		5LUZ 5LV0 8VJU 8VJV 8VJW 8VJX 8VJY	2HQ6 4R3E 5Z56 5Z58 6FF4 6FF7 6YVH 7DVQ 8I0R
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuropeptide Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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