HMCES

Name	5-hydroxymethylcytosine binding, ES cell specific
Structure
Novel Interactors	1 novel interactors: ACAD9
Interactors	3 interactors: APP FBXO25 NEDD4
GO Annotations	Cellular Component	Replication Fork Chromosome
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Peptidase Activity Hydrolase Activity Lyase Activity DNA-(abasic Site) Binding Protein-DNA Covalent Cross-linking Activity
	Biological Process	DNA Repair Proteolysis DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Interstrand Cross-link Repair Positive Regulation Of Isotype Switching Double-strand Break Repair Via Alternative Nonhomologous End Joining Protein-DNA Covalent Cross-linking Repair
GWAS	Hip circumference adjusted for BMI ( 34021172 )
Entrez ID	56941
HPRD ID	13119
Ensembl ID	ENSG00000183624
Uniprot IDs	E7EMP6 Q96FZ2
PDB IDs	5KO9 6OE7 6OEA 6OEB 6OOV
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Ubiquitin Ligase Complex Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Axon Choice Point Recognition Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Organization