HMCES and ACAD9

		HMCES	ACAD9
Description		5-hydroxymethylcytosine binding, ES cell specific	acyl-CoA dehydrogenase family member 9
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GO Annotations	Cellular Component	Replication Fork Chromosome	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Peptidase Activity Hydrolase Activity Lyase Activity DNA-(abasic Site) Binding Protein-DNA Covalent Cross-linking Activity	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	DNA Repair Proteolysis DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Interstrand Cross-link Repair Positive Regulation Of Isotype Switching Double-strand Break Repair Via Alternative Nonhomologous End Joining Protein-DNA Covalent Cross-linking Repair	Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process
Pathways			Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172)	Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		3 interacting genes: APP FBXO25 NEDD4
Entrez ID		56941	28976
HPRD ID		13119	12412
Ensembl ID		ENSG00000183624	ENSG00000177646
Uniprot IDs		E7EMP6 Q96FZ2	Q9H845 Q9H9W4
PDB IDs		5KO9 6OE7 6OEA 6OEB 6OOV	8PHE 8PHF
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Ubiquitin Ligase Complex Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Axon Choice Point Recognition Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Organization	Endoplasmic Reticulum Organization Pronephric Nephron Development Protein-DNA Covalent Cross-linking Activity Post-spliceosomal Complex Regulation Of DNA Recombination DNA-(abasic Site) Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Endosome Fission Endosome Membrane Tubulation Endoplasmic Reticulum-endosome Membrane Contact Site Signal Sequence Binding Membrane Tubulation Sec61 Translocon Complex MRNA 3'-splice Site Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein-DNA Covalent Cross-linking Repair Post-mRNA Release Spliceosomal Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nephron Development Somatic Hypermutation Of Immunoglobulin Genes DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Prp19 Complex U2-type Catalytic Step 1 Spliceosome Cotranslational Protein Targeting To Membrane
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