DUSP22

Name	dual specificity phosphatase 22
Structure
Interactors	6 interactors: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8 PTP4A2
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Protein Tyrosine Kinase Inhibitor Activity Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
GWAS	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Albumin-globulin ratio ( 29403010 ) Alopecia areata ( 25608926 ) Asthma (childhood onset) ( 31036433 ) Crohn's disease ( 26192919 ) Eosinophil count ( 32888494 ) Inflammatory bowel disease ( 26192919 ) Male-pattern baldness ( 28196072 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 29403010 ) Systemic lupus erythematosus ( 33536424 ) Takayasu arteritis ( 30498034 )
Entrez ID	56940
HPRD ID	13255
Ensembl ID	ENSG00000112679
Uniprot IDs	A0A384NLC8 Q9NRW4
PDB IDs	1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S
GO Terms Enriched among Interactors ?	Cellular Senescence MAP Kinase Activity MAP Kinase Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway JUN Kinase Kinase Activity MAPK Cascade Fc Receptor Signaling Pathway JNK Cascade Response To Light Stimulus Protein Serine Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Response To Radiation Protein Kinase Activity Regulation Of Motor Neuron Apoptotic Process Response To UV Cellular Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Kinase Activity Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Canonical Inflammasome Complex Assembly Intracellular Signaling Cassette Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Immune Response Response To Molecule Of Bacterial Origin Enzyme Binding Energy Homeostasis Immune Response-regulating Signaling Pathway Cellular Response To Mechanical Stimulus Semicircular Canal Formation JUN Phosphorylation Cellular Response To Lipid ATP Binding Abducens Nerve Formation Optokinetic Behavior Response To Tumor Necrosis Factor Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Immune System Process Regulation Of Synaptic Membrane Adhesion JUN Kinase Activity Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Transferase Activity Nucleotide Binding Intracellular Signal Transduction