NLRP2

Name	NLR family pyrin domain containing 2
Structure
Interactors	4 interactors: APP CARD8 FAF1 PYDC2
GO Annotations	Cellular Component	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Immune System Process Apoptotic Process Inflammatory Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
GWAS	Inflammatory bowel disease ( 23128233 ) Venous thromboembolism ( 31420334 )
Entrez ID	55655
HPRD ID	14805
Ensembl ID	ENSG00000022556
Uniprot IDs	A8K9G6 J3KN39 Q9NX02
PDB IDs	9C6V 9C6W 9C6X
GO Terms Enriched among Interactors ?	Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Cell Communication Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CARD8 Inflammasome Complex Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity Regulation Of Defense Response Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Particle Regulation Of Cytokine Production Positive Regulation Of Protein Import NACHT Domain Binding PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development