LGR4

Name	leucine rich repeat containing G protein-coupled receptor 4
Structure
Interactors	4 interactors: MARCHF2 RSPO1 RSPO3 RSPO4
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein-hormone Receptor Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cytokine Production Hair Follicle Development Immune System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Circadian Rhythm Wnt Signaling Pathway Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Tube Morphogenesis Intestinal Stem Cell Homeostasis Innate Immune Response Bone Remodeling Rhythmic Process Digestive Tract Development Epithelial Cell Proliferation Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways	Regulation of FZD by ubiquitination
GWAS	Blond vs. brown/black hair color ( 30531825 ) Bone mineral density ( 23644456 ) Bone mineral density (paediatric, skull) ( 24945404 ) Brain morphology (MOSTest) ( 32665545 ) Dental caries (decayed, missing and filled teeth) ( 31533690 ) Heel bone mineral density ( 30598549 ) Male-pattern baldness ( 28196072 ) Menarche (age at onset) ( 25231870 ) Spontaneous preterm birth with premature rupture of membranes ( 31194736 ) Survival in pancreatic cancer ( 28470677 ) Urate levels in obese individuals ( 25811787 )
Entrez ID	55366
HPRD ID	05978
Ensembl ID	ENSG00000205213
Uniprot IDs	Q59ER8 Q9BXB1
PDB IDs	4KT1 4QXE 4QXF 8WVU 8WVV 8WVW 8WVX 8WVY 8XFP 8XFS 8XFT 8XT9 8XUM 8Y69
GO Terms Enriched among Interactors ?	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Heparin Binding Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Signaling Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Nail Development Positive Regulation Of Protein Catabolic Process In The Vacuole Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Extracellular Space Regulation Of Lysosomal Protein Catabolic Process Suppression Of Viral Release By Host Antibacterial Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Signaling Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Extracellular Region Frizzled Binding Sprouting Angiogenesis Blood Vessel Remodeling