INO80

Name	INO80 complex ATPase subunit
Structure
Interactors	2 interactors: ACTN4 PLEKHF2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Ino80 Complex
	Molecular Function	Nucleotide Binding DNA Binding Actin Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Alpha-tubulin Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Mitotic Sister Chromatid Segregation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling DNA-templated Transcription DNA Damage Response Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Growth Regulation Of Chromosome Organization Cellular Response To UV Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Positive Regulation Of DNA Metabolic Process Spindle Assembly Chromosome Organization Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation UV-damage Excision Repair Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways	UCH proteinases DNA Damage Recognition in GG-NER
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Appendicular lean mass ( 33097823 ) Diastolic blood pressure ( 27841878 ) Estimated glomerular filtration rate ( 31451708 31152163 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Frailty index ( 34431594 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Macular thickness ( 30535121 ) Malaria ( 31844061 ) Menopause (age at onset) ( 26414677 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Systolic blood pressure ( 27841878 ) Ulcerative colitis ( 28067908 )
Entrez ID	54617
HPRD ID	10024
Ensembl ID	ENSG00000128908
Uniprot IDs	Q9ULG1
PDB IDs	6HTS 7ZI4
GO Terms Enriched among Interactors ?	Nucleoside Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Postsynaptic Actin Cytoskeleton Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Sodium Ion Transmembrane Transport Vesicle Transport Along Actin Filament Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Pseudopodium Retinoic Acid Receptor Signaling Pathway Vesicle Cytoskeletal Trafficking Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Platelet Alpha Granule Lumen Cellular Localization Tumor Necrosis Factor-mediated Signaling Pathway Protein Transport Establishment Of Protein Localization Positive Regulation Of Transporter Activity Nuclear Receptor Binding Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Actin Filament-based Movement Cortical Actin Cytoskeleton Establishment Of Localization In Cell Negative Regulation Of Cell-substrate Adhesion Intracellular Transport Endosome To Lysosome Transport Regulation Of Transmembrane Transporter Activity Muscle Cell Development Chromatin DNA Binding Intracellular Protein Localization Nuclear Receptor-mediated Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transporter Activity Stress Fiber Regulation Of Non-canonical NF-kappaB Signal Transduction Transport Vesicle Endosome Organization Establishment Of Vesicle Localization Phosphatidylinositol Binding Positive Regulation Of Cation Transmembrane Transport Vesicle Localization Positive Regulation Of Monoatomic Ion Transmembrane Transport Lysosomal Transport