PHKG1

Name	phosphorylase kinase catalytic subunit gamma 1
Structure
Novel Interactors	1 novel interactors: EGFR
Interactors	4 interactors: CALM1 CTRC MAPT PHKG2
GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphorylase Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylase Kinase Activity Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Signal Transduction
Pathways	Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs	Fostamatinib
GWAS	Macular telangiectasia type 2 ( 33654266 ) Multiple sclerosis ( 31604244 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 )
Entrez ID	5260
HPRD ID	01404
Ensembl ID	ENSG00000164776
Uniprot IDs	B7Z6U2 Q16816
PDB IDs	8JFK 8JFL 8XY7 8XYA 8XYB
GO Terms Enriched among Interactors ?	Regulation Of Calcium-mediated Signaling Enzyme Binding Multivesicular Body, Internal Vesicle Lumen Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Growth Membrane Raft Double-stranded DNA Binding Positive Regulation Of Growth Epidermal Growth Factor Binding ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Main Axon Regulation Of Tubulin Deacetylation Negative Regulation Of Mitochondrial Fission Negative Regulation Of Tubulin Deacetylation Lipoprotein Particle Binding Neurofibrillary Tangle Assembly Intracellular Distribution Of Mitochondria Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Regulation Of Glycogen Catabolic Process Cellular Response To Growth Factor Stimulus Learning Or Memory Cellular Response To Brain-derived Neurotrophic Factor Stimulus Inclusion Body Assembly Minor Groove Of Adenine-thymine-rich DNA Binding Salivary Gland Morphogenesis