MTRR

Name	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Structure
Novel Interactors	1 novel interactors: GFER
Interactors	2 interactors: GMCL1 MMAB
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding Molecular Carrier Activity
	Biological Process	Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process
Pathways	Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG Cobalamin (Cbl) metabolism
Drugs	Cyanocobalamin Methionine
Diseases	Spina bifida Homocystinuria
GWAS	Capecitabine sensitivity ( 22864933 ) Hyperinsulinemia in lower physical activity ( 30327367 ) Metabolite levels ( 23823483 ) Verbal declarative memory ( 25648963 )
Entrez ID	4552
HPRD ID	03979
Ensembl ID	ENSG00000124275
Uniprot IDs	Q9UBK8
PDB IDs	2QTL 2QTZ
GO Terms Enriched among Interactors ?	Flavin-dependent Sulfhydryl Oxidase Activity Mitochondrial Disulfide Relay System Corrinoid Adenosyltransferase Activity Thiol Oxidase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Cobalamin Metabolic Process Protein-disulfide Reductase Activity