MC3R

Name	melanocortin 3 receptor
Structure
Interactors	4 interactors: AGRP ASIP CFTR POMC
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Regulation Of Heart Rate Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Rhythmic Process Sodium Ion Homeostasis Regulation Of Feeding Behavior
Pathways	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs	Bremelanotide
GWAS	Adult body size ( 32376654 ) Body mass index ( 26426971 ) Body mass index (age <50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Metabolite levels ( 23823483 )
Entrez ID	4159
HPRD ID	01115
Ensembl ID	ENSG00000124089
Uniprot IDs	P41968
PDB IDs	8IOC 8KIG
GO Terms Enriched among Interactors ?	Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Long-day Photoperiodism Melanocortin Receptor Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Transepithelial Water Transport Regulation Of Hormone Secretion Positive Regulation Of Tooth Mineralization Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Peptide Hormone Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Amelogenesis Extracellular Space ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Feeding Behavior Melanin Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Cellular Response To Forskolin