ARSA

Name	arylsulfatase A
Structure
Novel Interactors	1 novel interactors: CYB5R3
Interactors	18 interactors: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process
Pathways	The activation of arylsulfatases Neutrophil degranulation Glycosphingolipid catabolism
Drugs	4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases	Metachromatic leukodystrophy (MLD)
GWAS	Aspartate aminotransferase levels ( 33547301 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) vWF and FVIII levels ( 30586737 )
Entrez ID	410
HPRD ID	09617
Ensembl ID	ENSG00000100299
Uniprot IDs	A0A0C4DFZ2 B4DVI5 P15289
PDB IDs	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8