CAPRIN1

Name	cell cycle associated protein 1
Structure
Novel Interactors	3 novel interactors: RAG1 RAG2 WT1
Interactors	10 interactors: APP CEBPA DAPK1 EIF2AK2 FXR2 MFHAS1 PIN1 PKNOX1 PRMT1 WBP4
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Intracellular Membraneless Organelle Synapse
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding ATP Binding Signaling Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nervous System Development Synapse Assembly Intracellular MRNA Localization Negative Regulation Of Translation Cell Differentiation Stress Granule Assembly Negative Regulation Of Translational Initiation Generation Of Neurons Positive Regulation Of Dendrite Morphogenesis Synapse Organization Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Stress Granule Assembly Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Membraneless Organelle Assembly
GWAS	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232 ) Major depressive disorder x sex interaction ( 34099189 ) Systolic blood pressure ( 30224653 )
Entrez ID	4076
HPRD ID	03108
Ensembl ID	ENSG00000135387
Uniprot IDs	Q14444
PDB IDs	4WBE 4WBP 6TA7 7XHG 8TH7
GO Terms Enriched among Interactors ?	Regulation Of Translation DNA Recombinase Complex Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Pre-B Cell Allelic Exclusion Negative Regulation Of Translation Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Nucleus Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Regulation Of Hematopoietic Stem Cell Proliferation Mononuclear Cell Differentiation Negative Regulation Of Gene Expression V(D)J Recombination Regulation Of Developmental Process Identical Protein Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Differentiation Positive Regulation Of P38MAPK Cascade T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Chromatin Organization Defense Response Regulation Of Cell Development Regulation Of Hemopoiesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Chromatin Binding Cellular Developmental Process Macromolecule Metabolic Process