HRH2

Name	histamine receptor H2
Structure
Novel Interactors	1 novel interactors: SLIT3
Interactors	1 interactors: GPRASP2
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Gastric Acid Secretion Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Vasoconstriction
Pathways	Histamine receptors G alpha (s) signalling events
Drugs	Betazole Amitriptyline Loxapine Cyproheptadine Cimetidine Nizatidine Epinastine Olopatadine Tolazoline Ranitidine Famotidine Methantheline Azelastine Promethazine Doxepin Aripiprazole HZT-501 Histamine Asenapine Metiamide Roxatidine acetate Viloxazine Niperotidine
GWAS	Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877 ) Mosquito bite size ( 28199695 ) Night sleep phenotypes ( 27126917 )
Entrez ID	3274
HPRD ID	00816
Ensembl ID	ENSG00000113749
Uniprot IDs	A0A1B0GTK7 P25021
PDB IDs	7UL3 8POK 8YN3 8YN4 8YUT
GO Terms Enriched among Interactors ?	Axon Extension Involved In Axon Guidance Response To Cortisol Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Roundabout Binding Roundabout Signaling Pathway Atrioventricular Valve Morphogenesis Hematopoietic Stem Cell Homeostasis Apoptotic Process Involved In Development Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Negative Chemotaxis Axon Extension Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Cardiac Septum Morphogenesis G Protein-coupled Receptor Binding