HDGF

Name	heparin binding growth factor
Structure
Novel Interactors	1 novel interactors: TRAF7
Interactors	7 interactors: APP CEBPA EIF4ENIF1 GPR37 JUN SMAD4 XBP1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Actin Binding Protein Binding Growth Factor Activity Heparin Binding Tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Signal Transduction Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division
Pathways	XBP1(S) activates chaperone genes
Drugs	Copper
GWAS	Blood protein levels ( 30072576 ) HDL cholesterol ( 24097068 ) HDL cholesterol levels ( 28334899 ) Refractive error ( 32231278 )
Entrez ID	3068
HPRD ID	02079
Ensembl ID	ENSG00000143321
Uniprot IDs	A0A384NPW1 A8K8G0 B7Z958 P51858
PDB IDs	1RI0 2NLU
GO Terms Enriched among Interactors ?	Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Gland Development Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Liver Development Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Signal Transduction Interleukin-6-mediated Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of RNA Metabolic Process Cell Maturation Neuron Projection Development Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Metal Ion Epithelial Cell Maturation SMAD Protein Signal Transduction Ubiquitin-like Protein Ligase Binding R-SMAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Microglial Cell Activation Carbohydrate Homeostasis Glucose Homeostasis Developmental Maturation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process