PYCR2

Name	pyrroline-5-carboxylate reductase 2
Structure
Interactors	6 interactors: APP CIC FXR1 FXR2 SKIL UBE4B
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress L-proline Biosynthetic Process
Pathways	Glutamate and glutamine metabolism
Drugs	NADH Proline
GWAS	No GWAS studies recorded
Entrez ID	29920
HPRD ID	17939
Ensembl ID	ENSG00000143811
Uniprot IDs	A0A087WTV6 A0A0S2Z5U6 Q96C36
PDB IDs	6LHM
GO Terms Enriched among Interactors ?	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Translation Regulator Activity Regulation Of Synaptic Plasticity Dentate Gyrus Development Presynapse Postsynapse Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Differentiation Neuron Projection Protein Heterodimerization Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Neurogenesis Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Development Regulation Of Nervous System Development Cytoplasmic Ribonucleoprotein Granule Granzyme-mediated Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Developmental Process MRNA Destabilization RNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Catabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Positive Regulation Of MRNA Catabolic Process Memory Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Transport