GRK4

Name	G protein-coupled receptor kinase 4
Structure
Novel Interactors	1 novel interactors: FGFR3
Interactors	7 interactors: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4 SNCA
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Photoreceptor Disc Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity
	Biological Process	Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Receptor Internalization
GWAS	Hip circumference adjusted for BMI ( 28552196 ) Household income (MTAG) ( 31844048 ) Mean platelet volume ( 32888494 ) Myocardial infarction ( 33532862 ) Smoking behaviour (cigarettes smoked per day) ( 30617275 )
Entrez ID	2868
HPRD ID	00656
Ensembl ID	ENSG00000125388
Uniprot IDs	P32298
PDB IDs	4YHJ
GO Terms Enriched among Interactors ?	Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Metal Ion Transport Positive Regulation Of Signal Transduction Regulation Of Autophagy Regulation Of Monoatomic Ion Transport Endocytosis Regulation Of Membrane Potential Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Positive Regulation Of Catabolic Process Receptor-mediated Endocytosis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor Complex Regulation Of Macroautophagy Import Into Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Domain Specific Binding Negative Regulation Of Signal Transduction Regulation Of Systemic Arterial Blood Pressure Presynaptic Endocytosis Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Establishment Of Localization In Cell Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Regulation Of Sodium Ion Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Cation Transmembrane Transport Response To Metal Ion Cell Surface Receptor Signaling Pathway Via JAK-STAT Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Formation Of Structure Involved In A Symbiotic Process