TSEN54

Name	tRNA splicing endonuclease subunit 54
Structure
Interactors	20 interactors: BRCA1 CCDC57 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing
Pathways	tRNA processing in the nucleus
Diseases	Pontocerebellar hypoplasia
GWAS	Deep white matter hyperintensities ( 32517579 ) FEV1 ( 30804560 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011 ) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370 )
Entrez ID	283989
HPRD ID	12291
Ensembl ID	ENSG00000182173
Uniprot IDs	Q7Z6J9
PDB IDs	7UXA 7ZRZ 8HMY 8HMZ 8ISS
GO Terms Enriched among Interactors ?	Medial Motor Column Neuron Differentiation