FBXL5

Name	F-box and leucine rich repeat protein 5
Structure
Interactors	10 interactors: CITED2 CSNK2B DCTN1 EP300 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Intracellular Iron Ion Homeostasis Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Inorganic Ion Homeostasis
Pathways	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
GWAS	Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Red blood cell count ( 32888494 )
Entrez ID	26234
HPRD ID	05739
Ensembl ID	ENSG00000118564
Uniprot IDs	Q9UKA1
PDB IDs	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
GO Terms Enriched among Interactors ?	Tau Protein Binding Protein Domain Specific Binding Protein Destabilization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly PcG Protein Complex Regulation Of Microtubule Cytoskeleton Organization Molecular Function Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytosol Regulation Of Microtubule-based Process Establishment Of Spindle Localization Establishment Of Spindle Orientation Regulation Of Mitotic Spindle Organization Nuclear Membrane Organization Establishment Of Mitotic Spindle Localization Microtubule Binding Establishment Of Organelle Localization Spindle Localization Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Localization To Chromatin Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Mitotic G2/M Transition Checkpoint Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission C-rich Strand Telomeric DNA Binding Response To Estrogen Regulation Of Microtubule Polymerization Protein-containing Complex Myeloid Cell Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleus Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Histone H2B Acetyltransferase Activity