FOLR1

Name	folate receptor alpha
Structure
Novel Interactors	2 novel interactors: INTS4 PDE2A
Interactors	6 interactors: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Folic Acid Binding Signaling Receptor Activity Folic Acid Receptor Activity
	Biological Process	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Response To Axon Injury Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid
Pathways	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs	Folic acid Vintafolide Farletuzumab Mirvetuximab soravtansine Pafolacianine
GWAS	No GWAS studies recorded
Entrez ID	2348
HPRD ID	00638
Ensembl ID	ENSG00000110195
Uniprot IDs	P15328
PDB IDs	4KM6 4KM7 4KMX 4LRH 5IZQ
GO Terms Enriched among Interactors ?	Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Lipopolysaccharide-mediated Signaling Pathway Nuclear RNA Surveillance RNA Surveillance Positive Regulation Of Chromosome Separation RNA Polymerase II Transcription Initiation Surveillance Mononuclear Cell Differentiation Nucleobase-containing Compound Catabolic Process Positive Regulation Of Macrophage Tolerance Induction Leukocyte Differentiation Regulation Of Chromosome Separation Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Oligodendrocyte Progenitor Proliferation Trophectodermal Cellular Morphogenesis Liver Morphogenesis Female Meiosis Chromosome Separation Leukotriene B4 Receptor Activity Response To Amino Acid Negative Regulation Of Catalytic Activity Regulation Of Oligodendrocyte Progenitor Proliferation Pattern Recognition Receptor Signaling Pathway Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Negative Regulation Of MAPK Cascade Myeloid Leukocyte Differentiation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Response To Insulin Interleukin-5-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Mitochondrion Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process Regulation Of Organelle Organization Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine