AP4E1

Name	adaptor related protein complex 4 subunit epsilon 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: SLC27A2
Interactors	3 interactors: AP4B1 ARF1 MTNR1B
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane Membrane Coat AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Cargo Adaptor Activity
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization
Pathways	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Diseases	Cerebral palsy
GWAS	Chloride levels ( 29403010 ) Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Height ( 31562340 ) Keratoconus ( 33649486 ) Potassium levels ( 29403010 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 )
Entrez ID	23431
HPRD ID	06258
Ensembl ID	ENSG00000081014
Uniprot IDs	B4DM48 Q9UPM8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Cleavage Furrow Ingression Mitotic Cleavage Furrow Ingression Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane Protein Localization To Somatodendritic Compartment Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep AP-4 Adaptor Complex Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Clathrin Adaptor Complex Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Negative Regulation Of Cytosolic Calcium Ion Concentration Long-chain Fatty Acid Transmembrane Transporter Activity Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell Regulation Of Transmission Of Nerve Impulse Copper Ion Homeostasis Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle Endosome Lumen Bile Acid Biosynthetic Process Intracellular Protein Transport Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Behavior Membrane Coat Dendritic Spine Organization Bile Acid Metabolic Process Regulation Of Actin Nucleation