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USP22

Name ubiquitin specific peptidase 22
Structure No pdb structure
Novel Interactors 1 novel interactors: B9D1
Interactors 17 interactors: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1
GO Annotations Cellular Component
  • SAGA Complex
  • Nucleus
  • Nucleoplasm
  • Cytoplasm
  • Transcription Factor TFTC Complex
Molecular Function
  • Transcription Coactivator Activity
  • Cysteine-type Deubiquitinase Activity
  • Protein Binding
  • Peptidase Activity
  • Cysteine-type Peptidase Activity
  • Zinc Ion Binding
  • Histone H4 Acetyltransferase Activity
  • Hydrolase Activity
  • Enzyme Binding
  • Metal Ion Binding
  • Histone H2B Deubiquitinase Activity
  • Histone H2A Deubiquitinase Activity
Biological Process
  • G2/M Transition Of Mitotic Cell Cycle
  • Regulation Of DNA Repair
  • Chromatin Organization
  • Chromatin Remodeling
  • Regulation Of Transcription By RNA Polymerase II
  • Proteolysis
  • Embryo Development Ending In Birth Or Egg Hatching
  • Protein Deubiquitination
  • Positive Regulation Of Type I Interferon Production
  • Regulation Of RNA Splicing
  • Positive Regulation Of DNA-templated Transcription
  • Positive Regulation Of Mitotic Cell Cycle
Pathways
  • HATs acetylate histones
  • Ub-specific processing proteases
GWAS
  • Body mass index ( 26426971 )
  • Mosquito bite size ( 28199695 )
Entrez ID 23326
HPRD ID 19411
Ensembl ID ENSG00000124422
Uniprot IDs Q9UPT9
PDB IDs Not available
GO Terms Enriched among Interactors ?
  • Protein Heterodimerization Activity
  • Structural Constituent Of Chromatin
  • Nucleosome

© Madhavi K. Ganapathiraju 2012-2026