FLT3LG

Name	fms related receptor tyrosine kinase 3 ligand
Structure
Interactors	5 interactors: FLT3 KITLG KRTAP5-9 PFN2 S100A6
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation
Pathways	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
GWAS	Monocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 )
Entrez ID	2323
HPRD ID	02477
Ensembl ID	ENSG00000090554
Uniprot IDs	B7ZLY4 P49771
PDB IDs	1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9
GO Terms Enriched among Interactors ?	Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure